Year: 2017 | Month: June | Volume 7 | Issue 3
Study on Neuroendocrine Disrupting Potential of Cadmium in Rats and Evaluation of Role of Green Tea
Abstract:
The protective role of green tea extract was studied in neuroendocrine disrupting actions of cadmium. Twenty four weaned Sprague dawley male rats were randomly divided into 4 groups of 6 rats in each .Group 1 served as Sham control, Group 2 was treated with CdCl2 @5mg/kg b.wt. per orally for 3 months, Group 3 was treated with Green tea extract(1.5%) and Group 4 with CdCl2 + green tea extract. The serum testosterone, Tri-iodothyronine (T3) and Thyroxine (T4) hormones were monitored at monthly interval. At the end of 3 months rats were sacrificed and testes were collected for estimation of thio barbituric acid reacting substance (TBARS), reduced GSH, protein carbonyls and sperm count. Before sacrifice, rats were subjected to elevated plus maze (EPM) and morris water maze (MWM). Administration of CdCl2 resulted in decrease of serum testosterone, T4 hormones, testicular GSH, sperm count and increase in serum T3 and testicular TBARS and protein carbonyls while, number of entries and time spent in open arm of EPM increased and the total distance travelled in MWM increased. Treatment with green tea significantly ameliorated (p<0.05) toxic effects of CdCl2 by restoring biochemical and hormonal profile to normal. It is concluded that green tea extract exhibits neuro-endocrine protective property in CdCl2 induced neuroendocrine disruption.
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